Journal
CIRCULATION JOURNAL
Volume 74, Issue 3, Pages 418-423Publisher
JAPANESE CIRCULATION SOC
DOI: 10.1253/circj.CJ-09-1021
Keywords
Cardioprotection; Chemokines; Endothelial progenitor cells; Leukocytes; Myocardial infarction
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labor and Welfare
- Takeda Science Foundation
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Myocardial infarction (MI) is accompanied by an inflammatory response, leading to the recruitment of leukocytes and subsequent myocardial injury and healing. Chemokines are potent chemoattractant cytokines that regulate leukocyte trafficking in inflammatory processes. Recent evidence indicates that chemokines play a role not only in leukocyte trafficking but also in angiogenesis and cardioprotection. In particular, stromal cell-derived factor-la (SDF-1 alpha) has generated considerable, interest for its role in the pathophysiology of MI. This review will focus on the role of SDF-1 and its receptor CXC chemokine receptor 4 (CXCR4; ie, the SDF-1/CXCR4 system) in the pathophysiology of MI and discuss their potential as therapeutic targets for MI. (Circ J 2010; 74: 418-423)
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