Journal
CIRCULATION
Volume 128, Issue 4, Pages 388-400Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCULATIONAHA.113.001878
Keywords
cardiac electrophysiology; fibrosis; inflammation; stem cells; ventricular remodeling
Funding
- National Institutes of Health [HL-080144, HL-0980842, HL-100401]
- Cancer Prevention and Research Institute of Texas (CPRIT) [RP110486P3]
- American Heart Association-DeHaan Foundation [0970518 N]
- Fondation Leducq [11CVD04]
Ask authors/readers for more resources
Despite declines in heart failure morbidity and mortality with current therapies, rehospitalization rates remain distressingly high, substantially affecting individuals, society, and the economy. As a result, the need for new therapeutic advances and novel medical devices is urgent. Disease-related left ventricular remodeling is a complex process involving cardiac myocyte growth and death, vascular rarefaction, fibrosis, inflammation, and electrophysiological remodeling. Because these events are highly interrelated, targeting a single molecule or process may not be sufficient. Here, we review molecular and cellular mechanisms governing pathological ventricular remodeling.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available