Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 25, Pages 7414-7417Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201502536
Keywords
ball milling; C-H functionalization; mechanochemistry; oxidative Heck reaction; rhodium catalysis
Categories
Funding
- RWTH Aachen University - from the Distinguished Professorship Program - Excellence Initiative of the German federal government
- RWTH Aachen University - from the Distinguished Professorship Program - Excellence Initiative of the German state government
Ask authors/readers for more resources
In a proof-of-principle study, a planetary ball mill was applied to rhodium(III)-catalyzed C-H bond functionalization. Under solventless conditions and in the presence of a minute amount of Cu(OAc)(2), the mechanochemical activation led to the formation of an active rhodium species, thus enabling an oxidative Heck-type cross-coupling reaction with dioxygen as the terminal oxidant. The absence of an organic solvent, the avoidance of a high reaction temperature, the possibility of minimizing the amount of the metallic mediator, and the simplicity of the protocol result in a powerful and environmentally benign alternative to the common solution-based standard protocol.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available