Journal
CIRCULATION
Volume 122, Issue 12, Pages 1192-1199Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCULATIONAHA.110.936674
Keywords
adiposity; birth weight; blood pressure; gestational hypertension; offspring; preeclampsia
Funding
- US National Institutes of Health [R01 DK077659]
- UK Medical Research Council
- Wellcome Trust
- University of Bristol
- Medical Research Council [G0600705]
- Medical Research Council [G9815508, G0701594, G0600705] Funding Source: researchfish
- MRC [G0600705, G0701594] Funding Source: UKRI
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Background-Offspring of women with hypertensive disorders of pregnancy are at increased risk of cardiovascular complications later in life, but the mechanisms underlying these associations are unclear. Our aim was to examine whether adjusting for birth weight and familial adiposity changed the association of hypertensive disorders of pregnancy with offspring blood pressure. Methods and Results-Using data from 6343 nine-year-old participants in the Avon Longitudinal Study of Parents and Children, we examined the association between hypertensive disorders of pregnancy (preeclampsia and gestational hypertension) and offspring blood pressure. Both preeclampsia and gestational hypertension were associated with systolic and diastolic blood pressures in the 9-year-old offspring; after adjustment for parental and own adiposity and for other potential confounders, the mean difference in systolic blood pressure was 2.05 mm Hg (95% confidence interval, 0.72 to 3.38) and 2.04 mm Hg (95% confidence interval, 1.42 to 2.67) for preeclampsia and gestational hypertension, respectively, compared with those with no hypertensive disorders of pregnancy. Equivalent results for diastolic blood pressure were 1.00 mm Hg (95% confidence interval, -0.01 to 2.10) and 1.07 mm Hg (95% confidence interval, 0.60 to 1.54). The association of preeclampsia with offspring systolic and diastolic blood pressures attenuated toward the null with further adjustment for birth weight and gestational age, whereas these adjustments did not attenuate the association of gestational hypertension with offspring blood pressure. Conclusions-The associations of hypertensive disorders of pregnancy with higher offspring blood pressure are not explained by familial adiposity. The mechanisms linking preeclampsia and gestational hypertension with offspring blood pressure may differ, with the former mediated at least in part by the effect of preeclampsia on intrauterine growth restriction. (Circulation. 2010;122:1192-1199.)
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