Journal
CIRCULATION
Volume 122, Issue 13, Pages 1258-1264Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCULATIONAHA.109.902148
Keywords
arrhythmia; long-term ECG; myocardial infarction; ventricular ejection fraction
Funding
- Medtronic Bakken Research Center, Maastricht, the Netherlands
- Cambridge Heart Inc, Cambridge, Mass
- Medtronic Inc
- St. Jude Medical
- Boston Scientific
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Background-Knowledge about the incidence of cardiac arrhythmias after acute myocardial infarction has been limited by the lack of traditional ECG recording systems to document and confirm asymptomatic and symptomatic arrhythmias. The Cardiac Arrhythmias and Risk Stratification After Myocardial Infarction (CARISMA) trial was designed to study the incidence and prognostic significance of arrhythmias documented by an implantable cardiac monitor among patients with acute myocardial infarction and reduced left ventricular ejection fraction. Methods and Results-A total of 1393 of 5869 patients (24%) screened in the acute phase (3 to 21 days) of an acute myocardial infarction had left ventricular ejection fraction <40%. After exclusions, 297 patients (21%) (mean +/- SD age, 64.0 +/- 11.0 years; left ventricular ejection fraction, 31 +/- 7%) received an implantable cardiac monitor within 11 +/- 5 days of the acute myocardial infarction and were followed up every 3 months for an average of 1.9 +/- 0.5 years. Predefined bradyarrhythmias and tachyarrhythmias were recorded in 137 patients (46%); 86% of these were asymptomatic. The implantable cardiac monitor documented a 28% incidence of new-onset atrial fibrillation with fast ventricular response (>= 125 bpm), a 13% incidence of nonsustained ventricular tachycardia (>= 16 beats), a 10% incidence of high-degree atrioventricular block (<= 30 bpm lasting >= 8 seconds), a 7% incidence of sinus bradycardia (<= 30 bpm lasting >= 8 seconds), a 5% incidence of sinus arrest (>= 5 seconds), a 3% incidence of sustained ventricular tachycardia, and a 3% incidence of ventricular fibrillation. Cox regression analysis with time-dependent covariates revealed that high-degree atrioventricular block was the most powerful predictor of cardiac death (hazard ratio, 6.75; 95% confidence interval, 2.55 to 17.84; P<0.001). Conclusions-This is the first study to report on long-term cardiac arrhythmias recorded by an implantable loop recorder in patients with left ventricular ejection fraction <= 40% after myocardial infarction. Clinically significant bradyarrhythmias and tachyarrhythmias were documented in a substantial proportion of patients with depressed left ventricular ejection fraction after acute myocardial infarction. Intermittent high-degree atrioventricular block was associated with a very high risk of cardiac death.
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