Journal
JOURNAL OF INHERITED METABOLIC DISEASE
Volume 38, Issue 4, Pages 681-702Publisher
SPRINGER
DOI: 10.1007/s10545-015-9819-7
Keywords
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Funding
- BBSRC [BB/K006231/1]
- Portuguese Foundation for Science and Technology (FCT)
- FEDER/COMPETE [PTDC/BIA-BCM/118605/2010, SFRH/BPD/90084/2012, FP-7-PEOPLE-2012-Marie Curie-ITN 316723 PERFUME]
- Biotechnology and Biological Sciences Research Council [BB/K006231/1] Funding Source: researchfish
- BBSRC [BB/K006231/1] Funding Source: UKRI
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/90084/2012, PTDC/BIA-BCM/118605/2010] Funding Source: FCT
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Peroxisomes and mitochondria are ubiquitous, highly dynamic organelles with an oxidative type of metabolism in eukaryotic cells. Over the years, substantial evidence has been provided that peroxisomes and mitochondria exhibit a close functional interplay which impacts on human health and development. The so-called peroxisome-mitochondria connection includes metabolic cooperation in the degradation of fatty acids, a redox-sensitive relationship, an overlap in key components of the membrane fission machineries and cooperation in anti-viral signalling and defence. Furthermore, combined peroxisome-mitochondria disorders with defects in organelle division have been revealed. In this review, we present the latest progress in the emerging field of peroxisomal and mitochondrial interplay in mammals with a particular emphasis on cooperative fatty acid beta-oxidation, redox interplay, organelle dynamics, cooperation in anti-viral signalling and the resulting implications for disease.
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