Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 1, Pages 321-325Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201508117
Keywords
alkenylation; C-H activation; homogeneous catalysis; indoles; rhodium
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Funding
- National Natural Science Foundation of China [21132008]
- Merck
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An efficient rhodium-catalyzed method for direct C-H functionalization at the C7 position of a wide range of indoles has been developed. Good to excellent yields of alkenylation products were observed with acrylates, styrenes, and vinyl phenyl sulfones, whereas the saturated alkylation products were obtained in good yield with alpha,beta-unsaturated ketones. Both the N-pivaloyl directing group and the rhodium catalyst proved to be crucial for high regioselectivity and conversion.
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