Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 213, Issue 9, Pages 1472-1475Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiv752
Keywords
artemisinin resistance; K13; Plasmodium falciparum; malaria; South America; Guyana; ACT
Categories
Funding
- Centers for Disease Control and Prevention (CDC) Antimicrobial Resistance Working Group
- Amazon Malaria Initiative
- US Agency for International Development
- American Society of Microbiology/CDC
- Atlanta Research and Education Foundation
- Atlanta VA Medical Center
Ask authors/readers for more resources
Suspected artemisinin resistance in Plasmodium falciparum can be explored by examining polymorphisms in the Kelch (PfK13) propeller domain. Sequencing of PfK13 and other gene resistance markers was performed on 98 samples from Guyana. Five of these samples carried the C580Y allele in the PfK13 propeller domain, with flanking microsatellite profiles different from those observed in Southeast Asia. These molecular data demonstrate independent emergence of the C580Y K13 mutant allele in Guyana, where resistance alleles to previously used drugs are fixed. Therefore, in Guyana and neighboring countries, continued molecular surveillance and periodic assessment of the therapeutic efficacy of artemisinin-based combination therapy are warranted.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available