Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 212, Issue 5, Pages 711-714Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiv122
Keywords
adult; dengue hemorrhagic fever; endothelial function; nitric oxide; noninvasive; peripheral arterial tone; reactive hyperemia index; vascular
Categories
Funding
- National Medical Research Council, Singapore [NMRC/TCR/005/2008]
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In a prospective longitudinal adult study, vascular nitric oxide bioavailability measured as reactive hyperemia index was significantly higher at enrollment in patients who developed dengue hemorrhagic fever (DHF) (n = 11), compared with the non-DHF group (n = 63) and those with other febrile illnesses (n = 25) (P = .01). After adjustment for age, fever day, and body mass index, enrollment reactive hyperemia index was associated with a 4-fold increased risk for DHF, and predicted DHF with an area under the receiver operating curve of 0.86. Increased vascular nitric oxide in dengue is associated with increased vascular permeability and impaired homeostasis and may have utility as a predictor of DHF.
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