Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 213, Issue 4, Pages 669-673Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiv467
Keywords
Helicobacter pylori; cagA promoter region; CagA expression; IL-8
Categories
Funding
- Programa Operacional Factores de Competitividade-COMPETE (FEDER funds)
- Fundacao para a Ciencia e a Tecnologia Project [PTDC/SAU-SAP/120024/2010, SFRH/BPD/84084/2012]
- Fundação para a Ciência e a Tecnologia [PTDC/SAU-SAP/120024/2010] Funding Source: FCT
Ask authors/readers for more resources
Heterogeneity at the Helicobacter pylori cagA gene promoter region has been linked to variation in CagA expression and gastric histopathology. Here, we characterized the cagA promoter and expression in 46 H. pylori strains from Portugal. Our results confirm the relationship between cagA promoter region variation and protein expression originally observed in strains from Colombia. We observed that individuals with intestinal metaplasia were all infected with H. pylori strains containing a specific cagA motif. Additionally, we provided novel functional evidence that strain-specific sequences in the cagA promoter region and CagA expression levels influence interleukin 8 secretion by the host gastric epithelial cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available