Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 212, Issue 7, Pages 1052-1060Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiv181
Keywords
avian influenza viruses; H7N9 subtype; H5N1 subtype; antibody-dependent cellular cytotoxicity; antibody-dependent cell-mediated cytotoxicity; ADCC, complement-dependent lysis; hemagglutination-inhibition; non-neutralizing antibody
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Funding
- National Institutes of Allergy and Infectious Diseases [HHSN272201400005C, HHSN272201200005C]
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Human influenza is a highly contagious acute respiratory illness that is responsible for significant morbidity and excess mortality worldwide. In addition to neutralizing antibodies, there are antibodies that bind to influenza virus-infected cells and mediate lysis of the infected cells by natural killer (NK) cells (antibody-dependent cellular cytotoxicity ADCC]) or complement (complement-dependent lysis CDL]). We analyzed sera obtained from 16 healthy adults (18-63 years of age), 52 children (2-17 years of age), and 10 infants (0.75-1 year of age) in the United States, who were unlikely to have been exposed to the avian H7N9 subtype of influenza A virus, by ADCC and CDL assays. As expected, none of these sera had detectable levels of hemagglutination-inhibiting antibodies against the H7N9 virus, but we unexpectedly found high titers of ADCC antibodies to the H7N9 subtype virus in all sera from adults and children aged >= 8 years.
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