Journal
CHRONOBIOLOGY INTERNATIONAL
Volume 30, Issue 7, Pages 870-888Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07420528.2013.782315
Keywords
Adaptive immune response; allergic reaction; circadian rhythm; clock gene; cytokine; innate immune response
Categories
Funding
- Italian Ministry of Health through Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit [RC1203ME46]
- Canadian Institutes for Health Research
- Natural Science and Engineering Research Council
- Fonds de Recherche du Quebec-Sante
- National Institutes of Health [R37 AA08757, R01 AA015718, R01 HL088041]
- IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy
Ask authors/readers for more resources
Various features, components, and functions of the immune system present daily variations. Immunocompetent cell counts and cytokine levels present variations according to the time of day and the sleep-wake cycle. Moreover, different immune cell types, such as macrophages, natural killer cells, and lymphocytes, contain a circadian molecular clockwork. The biological clocks intrinsic to immune cells and lymphoid organs, together with inputs from the central pacemaker of the suprachiasmatic nuclei via humoral and neural pathways, regulate the function of cells of the immune system, including their response to signals and their effector functions. Consequences of this include, for example, the daily variation in the response to an immune challenge (e. g., bacterial endotoxin injection) and the circadian control of allergic reactions. The circadian-immune connection is bidirectional, because in addition to this circadian control of immune functions, immune challenges and immune mediators (e. g., cytokines) were shown to have strong effects on circadian rhythms at the molecular, cellular, and behavioral levels. This tight crosstalk between the circadian and immune systems has wide-ranging implications for disease, as shown by the higher incidence of cancer and the exacerbation of autoimmune symptoms upon circadian disruption.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available