Journal
CHRONOBIOLOGY INTERNATIONAL
Volume 27, Issue 6, Pages 1317-1328Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07420528.2010.489166
Keywords
Circadian rhythms; Diet-induced obesity; Metabolism; Mouse; mPeriod
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Funding
- DFG [DA525/2-1]
- National Institutes of Health [NS056125]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS056125] Funding Source: NIH RePORTER
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The circadian clock orchestrates most physiological processes in mammals. Disruption of circadian rhythms appears to contribute to the development of obesity and metabolic syndrome. The Period genes mPer1 and mPer2, but not mPer3, are essential for core clock function in mice. To assess the impact of mPer genes on body mass regulation, mPer mutant and control mice were fed a high-fat diet. Here the authors report that male mPer1/2/3 triple-deficient mice gain significantly more body mass than wild-type controls on high-fat diet. Surprisingly, mPer3 single-deficient animals mimicked this phenotype, suggesting a previously unrecognized role for mPer3 in body mass regulation. (Author correspondence: Robert@dallmanns.de)
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