Journal
CHRONOBIOLOGY INTERNATIONAL
Volume 26, Issue 2, Pages 258-281Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07420520902772221
Keywords
Multivariate permutation tests; Treatment effects; Time series; Fourier analysis; Biological rhythms
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Funding
- National Institute of Mental Health [K01 MH083052, K23 MH01828]
- National Institute of Child Health and Development [P30 HD15052]
- Stanley Foundation
- NARSAD
- Pfizer
- National Center for Research Resources [M01 RR0095]
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Treatment-related changes in neurobiological rhythms are of increasing interest to psychologists, psychiatrists, and biological rhythms researchers. New methods for analyzing change in rhythms are needed, as most common methods disregard the rich complexity of biological processes. Large time series data sets reflect the intricacies of underlying neurobiological processes, but can be difficult to analyze. We propose the use of Fourier methods with multivariate permutation test (MPT) methods for analyzing change in rhythms from time series data. To validate the use of MPT for Fourier-transformed data, we performed Monte Carlo simulations and compared statistical power and family-wise error for MPT to Bonferroni-corrected and uncorrected methods. Results show that MPT provides greater statistical power than Bonferroni-corrected tests, while appropriately controlling family-wise error. We applied this method to human, pre- and post-treatment, serially-sampled neurotransmitter data to confirm the utility of this method using real data. Together, Fourier with MPT methods provides a statistically powerful approach for detecting change in biological rhythms from time series data.
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