4.2 Article

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

Journal

CHROMOSOME RESEARCH
Volume 21, Issue 2, Pages 101-106

Publisher

SPRINGER
DOI: 10.1007/s10577-013-9347-y

Keywords

centromere; CENP-A; histone; kinetochore; CenH3

Funding

  1. Wellcome Trust [073915, 095021]
  2. NIH [R01-GM082989, GM088313, GM074150, R01GM088371, 5R01GM61169, GM083988, R01GM088716, R37GM024364, R01GM074728, R01 GM063045, R01 GM098500, GM059618, GM69429, CA06927]
  3. Career Award in the Biomedical Sciences from the Burroughs Wellcome Fund
  4. Rita Allen Foundation Scholar Award
  5. National Science Foundation [MCB-1121563]
  6. Cabinet Office, Government of Japan, through its 'Funding Program for Next Generation World-Leading Researchers' [LS122]
  7. EMBO Installation Grant
  8. European Community's Seventh Framework Programme [241548, 258068]
  9. ERC Starting Grant [281198]
  10. Cancer Research UK
  11. MRC
  12. NIH/NIGMS [R01-50412]
  13. Oklahoma Center for Advancement of Science and Technology
  14. McCasland Foundation
  15. European Research Council
  16. Japanese Society for the Promotion of Science (JSPS)
  17. Ministry of Education, Culture, Sports, Science and Technology in Japan (MEXT)
  18. FCT [BIA-BCM/100557/2008, BIAPRO/100537/2008]
  19. ERC (KINSIGN)
  20. Netherlands Organisation for Scientific Research [NWO-Vici-016.130.661, NWO-Vici-91812610]
  21. Dutch Cancer Society [UU2009-4311, UU2011-5134]
  22. Spanish Ministry of Economy [CSD2007-015, SAF2010-25157]
  23. EU
  24. FCT (COMPETE-FEDER) [PTDC/SAU-GMG/099704/2008, PTDC/SAU-ONC/112917/2009]
  25. Human Frontier Science Program
  26. BBSRC [BB/I021353/1, BB/H013024]
  27. Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
  28. Kazusa DNA Research Institute Foundation
  29. CCSRI [700824]
  30. Swiss National Foundation, University of Geneva
  31. Foundation Louis-Jeantet
  32. March of Dimes [6-FY10-294]
  33. Science Foundation Ireland [12/IA/1370]
  34. Fundacao para Ciencia e Tecnologia of Portugal
  35. COMPETE
  36. ON2
  37. NSF [1024973]
  38. [077707]
  39. [092076]
  40. [R37 GM32238]
  41. Grants-in-Aid for Scientific Research [23247030] Funding Source: KAKEN
  42. Biotechnology and Biological Sciences Research Council [BB/I021353/1] Funding Source: researchfish
  43. Cancer Research UK [11431] Funding Source: researchfish
  44. Medical Research Council [G1001696] Funding Source: researchfish
  45. Fundação para a Ciência e a Tecnologia [PTDC/BIA-PRO/100537/2008, PTDC/SAU-ONC/112917/2009, PTDC/SAU-GMG/099704/2008, PTDC/BIA-BCM/100557/2008] Funding Source: FCT
  46. European Research Council (ERC) [281198] Funding Source: European Research Council (ERC)
  47. Direct For Biological Sciences
  48. Div Of Molecular and Cellular Bioscience [1121563, 1244146, 0758577] Funding Source: National Science Foundation
  49. Direct For Biological Sciences
  50. Div Of Molecular and Cellular Bioscience [1024973] Funding Source: National Science Foundation
  51. BBSRC [BB/I021353/1] Funding Source: UKRI
  52. MRC [G1001696] Funding Source: UKRI
  53. Science Foundation Ireland (SFI) [12/IA/1370] Funding Source: Science Foundation Ireland (SFI)

Ask authors/readers for more resources

The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.

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