Journal
CHROMOSOME RESEARCH
Volume 17, Issue 5, Pages 603-619Publisher
SPRINGER
DOI: 10.1007/s10577-009-9054-x
Keywords
X chromosome; MSL; Drosophila; transcription; chromatin; roX RNA; acetylation
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In Drosophila, dosage compensation of the single male X chromosome involves upregulation of expression of X linked genes. Dosage compensation complex or the male specific lethal (MSL) complex is intimately involved in this regulation. The MSL complex members decorate the male X chromosome by binding on hundreds of sites along the X chromosome. Recent genome wide analysis has brought new light into X chromosomal regulation. It is becoming increasingly clear that although the X chromosome achieves male specific regulation via the MSL complex members, a number of general factors also impinge on this regulation. Future studies integrating these aspects promise to shed more light into this epigenetic phenomenon.
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