Journal
CHROMOSOME RESEARCH
Volume 17, Issue 2, Pages 265-275Publisher
SPRINGER
DOI: 10.1007/s10577-008-9014-x
Keywords
bacterial SMC; MukB; chromosome segregation; DNA repair; cell cycle
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Bacteria and archaea possess several different SMC-like proteins, which perform essential functions in a variety of chromosome dynamics, such as chromosome compaction, segregation, and DNA repair. SMC-like proteins localize to distinct sites within the cells at different time points in the cell cycle, or are recruited to sites of DNA breaks and damage. The bacterial SMC (MukB) complex appears to perform a condensin-like function, while SbcC and RecN act early during DNA repair, but apparently at different sites within the cells. Thus, bacterial SMC-like proteins have dynamic functions in chromosome segregation and maintenance of genetic stability.
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