Journal
CHROMOSOMA
Volume 119, Issue 4, Pages 351-360Publisher
SPRINGER
DOI: 10.1007/s00412-010-0262-0
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Funding
- DFG
- Swedish Science Research Council
- Swedish Cancer Research Foundation
- Swedish Pediatric Cancer Foundation
- Lundberg Foundation
- EU
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More than 10(9) base pairs of the genome in higher eucaryotes are positioned in the interphase nucleus such that gene activation, gene repression, remote gene regulation by enhancer elements, and reading as well as adjusting epigenetic marks are possible. One important structural and functional component of chromatin organization is the zinc finger factor CTCF. Two decades of research has advanced the understanding of the fundamental role that CTCF plays in regulating such a vast expanse of DNA.
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