Journal
CHROMOSOMA
Volume 118, Issue 5, Pages 567-574Publisher
SPRINGER
DOI: 10.1007/s00412-009-0227-3
Keywords
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Funding
- Fundacao para a Ciencia e Tecnologia (FCT) [SFRH/BD/33219/2007]
- FCT
- Fundacao Calouste Gulbenkian
- EU Seventh Framework Program (FP7)
- EMBO installation
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Centromeres, the chromosomal loci that form the sites of attachment for spindle microtubules during mitosis, are identified by a unique chromatin structure generated by nucleosomes containing the histone H3 variant CENP-A. The apparent epigenetic mode of centromere inheritance across mitotic and meiotic divisions has generated much interest in how CENP-A assembly occurs and how structurally divergent centromeric nucleosomes can specify the centromere complex. Although a substantial number of proteins have been implicated in centromere assembly, factors that can bind CENP-A specifically and deliver nascent protein to the centromere were, thus far, lacking. Several recent reports on experiments in fission yeast and human cells have now shown significant progress on this problem. Here, we discuss these new developments and their implications for epigenetic centromere inheritance.
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