Journal
CHROMOSOMA
Volume 118, Issue 5, Pages 537-548Publisher
SPRINGER
DOI: 10.1007/s00412-009-0219-3
Keywords
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Funding
- NHLBI [R15]
- Department of Biology, Bowdoin College
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The interphase nucleus and nuclear envelope can acquire a myriad of shapes in normal or pathological cell states. There exist a wide variety of indentations and invaginations, of protrusions and evaginations. It has been difficult to classify and name all of these nuclear shapes and, consequently, a barrier to understanding the biochemical and biophysical causes. This review focuses upon one type of nuclear envelope shape change, named nuclear envelope-limited chromatin sheets (ELCS), which appears to involve exaggerated nuclear envelope growth, carrying with it one or more layers of similar to 30 nm diameter heterochromatin. A hypothesis on the formation of ELCS is proposed, relating higher order heterochromatin structure in an interphase nucleus, nuclear envelope growth, and nuclear envelope-heterochromatin interactions.
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