Journal
CHROMATOGRAPHIA
Volume 72, Issue 9-10, Pages 941-947Publisher
SPRINGER HEIDELBERG
DOI: 10.1365/s10337-010-1735-2
Keywords
Gas chromatography-mass spectrometry; Solid phase microextraction; Chiral separation; Camphor; Menthol
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A GC-MS method is proposed for the analysis of camphor and menthol in over-the-counter (OTC) products. Sample preparation was achieved by head-space solid phase microextraction using a polydimethylsiloxane fibre. GC analysis was performed using a Phenomenex ZB-5 column and a temperature program was adopted. The method was validated by studying linearity (range 0.1-15.0% w/w), accuracy, reproducibility and sensitivity. Applications were directed to the determination of the active ingredients in four different OTC-products; the mean recoveries were in the ranges 91.30-99.74% and 94.34-102.89% for camphor and menthol, respectively and the LOD was in the order of 0.005% (w/w). Other important terpenoids (alpha- and beta-pinene, 1,8-cineole, menthone, isomenthone, alpha-terpineole, t-cinnamaldehyde, eugenole) were identified by mass spectra and Kovats retention indices and quantified by peak area normalization to 100%. Further information for a comprehensive characterization of the OTC-products was achieved by the GC chiral analysis on a Cyclosil B capillary column.
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