Journal
CHROMATOGRAPHIA
Volume 68, Issue 11-12, Pages 1039-1044Publisher
SPRINGER HEIDELBERG
DOI: 10.1365/s10337-008-0808-y
Keywords
Contactless conductivity detection; Glass/PDMS; Hybrid microchips
Funding
- National Natural Science Foundation of China (NSFC) [20375049, 20575080, 20727006]
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A new glass/PDMS hybrid chip for contactless conductivity detection is reported. This chip consists of a glass substrate with microchannels and a PDMS cover sheet embedded with a small integrated electrode plate. In the region of detection, electrodes are insulated from the microchannel by a formed PDMS membrane about 100 mu m in thickness. Without any modification, this glass/PDMS chip is suitable for contactless conductivity detection with good properties, such as excellent heat-dissipation, stable electroosmotic flow, high separation efficiency, satisfactory sensitivity, simple construction and high degree of integration. Its feasibility and performance had been demonstrated by analyzing inorganic ions and amino acids in mixtures, and alkaloids in traditional Chinese medicine. The limits of detection reached micromole per liter (mu mol L-1) levels. This microchip could be promising for mass production due to its stability, reproducibility, ease of fabrication and low cost.
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