Journal
CHIRALITY
Volume 24, Issue 6, Pages 459-462Publisher
WILEY
DOI: 10.1002/chir.22012
Keywords
Sonneratia hainanensis; Sonneratiaceae; alkylresorcinol dimers
Funding
- Natural Marine 863 Project [2011AA09070102]
- Natural Science Foundation of China [40976048, 30730108, 21021063]
- STCSM International Cooperation Project between SIMM/China
- ICB/Italy [10540702900]
- NSFC-TRF [20911140471]
- Foundation of SIMM/SKLDR [SIMM1105KF-04, SIMM1106KF-11]
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Integracins A (1) and B (2), potent HIV-1 integrase inhibitors, and 15'-dehydroxy-integracin B (3) were isolated for the first time from Chinese mangrove plant Sonneratia hainanensis. Their absolute configurations were determined by the Mosher's method and specific rotation analysis of alcohols (6 and 7) obtained from integracin A in two steps and by chemical correlation. Integracin A (1) also exhibited significant cytotoxicity against the tumor cell lines HepG2 and NCI-H460 with both 100% inhibitions at 25?mu g/ml. Chirality 24:459462, 2012. (c) 2012 Wiley Periodicals, Inc.
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