Journal
CHIRALITY
Volume 24, Issue 3, Pages 255-261Publisher
WILEY-BLACKWELL
DOI: 10.1002/chir.21994
Keywords
asymmetric catalysis; diethylzinc reaction; dual stereoselection; ketopinic acid; hydroxyamides
Ask authors/readers for more resources
The screening of the catalytic activity in the diethylzinc reaction of a series of easily accessible (1S)-ketopinic-acid derived hydroxyamides, designed by key structure modifications of a parent highly active related bis(hydroxyamide), has allowed to find the first case of dual stereoselection in highly structurally close ligands of such interesting chemically sustainable typology. The found striking dual stereoselection is explained on the basis of empiric models for the acting zinc catalysts and involved controlling transition states, which are supported by additional specific experimental structure-activity tests. Chirality, 2012. (C) 2012 Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available