4.3 Review

Recent Advances in Asymmetric Oxidative Coupling of 2-Naphthol and its Derivatives

Journal

CHIRALITY
Volume 22, Issue 9, Pages 827-837

Publisher

WILEY
DOI: 10.1002/chir.20843

Keywords

oxidative coupling; enantioselective synthesis; chiral ligand; BINOLs

Funding

  1. Scientific Research Foundation of the Education Ministry for Returned Chinese Scholars, Fudan University Youth Scientific Foundation

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The enantiomeric atropoisomers of 1,10-binaphthyl-2,20-diol (BINOL) have become one of the most widely used chiral ligands and auxiliaries for asymmetric synthesis. This review provides an overview of enantioselective synthesis of optical active BINOLs by straightforward asymmetric oxidative coupling of identical 2-naphthol and its substituted derivatives. Chirality 22:827-837, 2010. (C) 2010 Wiley-Liss, Inc.

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