Journal
CHIRALITY
Volume 22, Issue 1, Pages 165-172Publisher
WILEY
DOI: 10.1002/chir.20722
Keywords
chiral recognition; chiral separation; chiral stationary phase; chiral packing materials; high-performance liquid chromatography; HPLC; immobilization; polysaccharide derivative
Funding
- Daicel Chemical Industries
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A small amount of 4-(trimethoxysilyl)phenyl groups was randomly introduced onto the 3,5-dimethylphenylcarbamates of cellulose and amylose by a one-pot method. The obtained derivatives were then effectively immobilized onto silica gel as chiral packing materials (CPMs) for high-performance liquid chromatography through intermolecular polycondensation of the trimethoxysilyl groups. The effects of the amount of 4-(trimethoxysilyl)phenyl groups on immobilization and enantioseparation were investigated. Also, the solvent durability of the immobilized-type CPMs was examined with the eluents containing chloroform and tetrahydrofuran. When these eluents were used, the chiral recognition abilities of the CPMs for most of the tested race-mates were improved to some extent depending on the compounds. Chirality 22:165-172, 2010. (C) 2009 Wiley-Liss, Inc.
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