Journal
CHIRALITY
Volume 22, Issue 10, Pages 914-921Publisher
WILEY-BLACKWELL
DOI: 10.1002/chir.20859
Keywords
capillary electrophoresis; enantioseparation; cationic beta-cyclodextrin; amino acids
Funding
- Shaanxi Province Science and Technology Key Project [2007K12-02(19)]
- National Natural Science Foundation of China [20702063]
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A novel single isomer of positively charged beta-cyclodextrin, mono-6-deoxy-6-(( 2S,3S)-(+)-2,3-O-isopropylidene-1,4-tetramethylenediamine)-beta-CD (MIPTACD) was designed and synthesized in seven steps starting from commercially available (2R,3R)-tartaric acid. The chiral resolution abilities of the new cationic chiral selector were studied by capillary electrophoresis using 10 different dansyl (Dns)-amino acids and N-acetylphenylalanine (N-Ac-Phe) as model analytes. The effects of running buffer pH and chiral selector concentration on the separation selectivity, resolutions, and migration times of analytes were studied in detail. MIPTACD shows a very good chiral recognition ability even at very low concentrations at the investigated pH values, as shown by the very large values of selectivity and resolution towards amino acids enantiomers to be assessed. Chirality 22:914-921, 2010. (C) 2010 Wiley-Liss, Inc.
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