Journal
CHIRALITY
Volume 21, Issue 1, Pages 208-217Publisher
WILEY
DOI: 10.1002/chir.20641
Keywords
chiral capillary electrophoresis; micellar capillary electrophoresis; tris(diimine)ruthenium(II); complexes; transition metal complexes; cyclodextrin; enantioseparation; micelle/sodium dodecylsulfate
Funding
- NIH [5 ROICM053825-11]
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Capillary zone electrophoresis (CZE) and micellar capillary electrophoresis (MCE) were applied for the enantiomeric separation of nine mononuclear tris(diimine)ruthenium(II) complexes as well as the separation of all stereoisomers of a dinuclear tris (diimine) ruthenium OD complex. Nine cyclodextrin (CD) based chiral selectors were examined as run buffer additives to evaluate their effectiveness in the enantiomeric separation of tris(diimine)ruthenium(II) complexes. Seven showed enantioselectivity. Sulfated gamma-cyclodextrin (SGC), with four baseline and three partial separations, was found to be the most useful chiral selector. In CZE mode, the derivatized gamma-CDs were more effective than beta-CDs while sulfated CDs work better than carboxymethyl CDs. In MCE mode, hydroxypropyl beta-CD separated the greatest number of tris(diimine) ruthenium(II) complexes. The effects of chiral selector concentration, run buffer pH and concentration, the concentration ratio between chiral selector and other factors were investigated. Chirality 21:208-217, 2009. (C) 2008 Wiley-Liss. Inc.
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