Journal
CHIRALITY
Volume 21, Issue 1, Pages 35-43Publisher
WILEY
DOI: 10.1002/chir.20591
Keywords
vitamin E; tocols; garcinoic acid; exciton-coupled CD; molecular dynamics; TDDFT calculations
Funding
- Ministero dell'Universita e della Mcerca [R13PR05NWWC]
Ask authors/readers for more resources
Vitamin E is an essential nutrient of still increasing economic importance. Vitamin E derivatives include many nonracemic chiral compounds whose chirooptical characterization is scarcely described in the literature. We report the CD spectra of delta-tocopherol and its unsaturated analog delta-tocotrienol. TDDFT calculations demonstrate that the weak CD of delta-tocopherol is determined by the helicity of dihydropyrane ring. In addition, the moderate CD of delta-tocotrienol is due to the exciton interaction between the aromatic ring and the closest alkene group. Direct exciton-coupled CD calculations on structures generated by two different conformational sampling approaches reveal that, although such exciton coupling is expected to be weak, it is sufficient to explain the spectral differences between tocopherol and tocotrienol. Chirality 21:35-43, 2009. (C) 2008 Wiley-Liss, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available