Journal
CHIRALITY
Volume 20, Issue 3-4, Pages 441-445Publisher
WILEY
DOI: 10.1002/chir.20461
Keywords
10,11-didehydro Cinchona alkaloids; Cinchona alkaloids; quinine; elimination; alkynes
Ask authors/readers for more resources
A revised procedure for the conversion of the four major Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) into their respective 10,11-didehydro derivatives is described. The reported protocol offers several advantages over a recently published synthetic route. These include (i) enhanced robustness (ii) ready scalability (iii) reduced operational complexity and number of steps (iv) chromatography-free work-up. In addition, toxic solvents were replaced by environmentally less problematic alternatives.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available