Related references
Note: Only part of the references are listed.Targeted Metagenomics: Finding Rare Tryptophan Dimer Natural Products in the Environment
Fang-Yuan Chang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)
Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors
Jeremy G. Owen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters
Daniel Montiel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Socially mediated induction and suppression of antibiosis during bacterial coexistence
Monica I. Abrudan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Global Biogeographic Sampling of Bacterial Secondary Metabolism
Zachary Charlop-Powers et al.
ELIFE (2015)
Targeted metagenomics as a tool to tap into marine natural product diversity for the discovery and production of drug candidates
Marla Trindade et al.
FRONTIERS IN MICROBIOLOGY (2015)
Arixanthomycins A-C: Phylogeny-Guided Discovery of Biologically Active eDNA-Derived Pentangular Polyphenols
Hahk-Soo Kang et al.
ACS CHEMICAL BIOLOGY (2014)
Characterization of an Environmental DNA-Derived Gene Cluster that Encodes the Bisindolylmaleimide Methylarcyriarubin
Fang-Yuan Chang et al.
CHEMBIOCHEM (2014)
eSNaPD: A Versatile, Web-Based Bioinformatics Platform for Surveying and Mining Natural Product Biosynthetic Diversity from Metagenomes
Boojala Vijay B. Reddy et al.
CHEMISTRY & BIOLOGY (2014)
Mining the Metabiome: Identifying Novel Natural Products from Microbial Communities
Aleksandr Milshteyn et al.
CHEMISTRY & BIOLOGY (2014)
The Chemical Arsenal of Burkholderia pseudomallei Is Essential for Pathogenicity
John B. Biggins et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Mining Soil Metagenomes to Better Understand the Evolution of Natural Product Structural Diversity: Pentangular Polyphenols as a Case Study
Hahk-Soo Kang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
An environmental bacterial taxon with a large and distinct metabolic repertoire
Micheal C. Wilson et al.
NATURE (2014)
Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont
Toshiyuki Wakimoto et al.
NATURE CHEMICAL BIOLOGY (2014)
Chemical-biogeographic survey of secondary metabolism in soil
Zachary Charlop-Powers et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A
Kazuya Yamanaka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074
Carlos Olano et al.
MICROBIAL BIOTECHNOLOGY (2014)
Selective Enrichment of Environmental DNA Libraries for Genes Encoding Nonribosomal Peptides and Polyketides by Phosphopantetheine Transferase-Dependent Complementation of Siderophore Biosynthesis
Zachary Charlop-Powers et al.
ACS CHEMICAL BIOLOGY (2013)
Arimetamycin A: Improving Clinically Relevant Families of Natural Products through Sequence-Guided Screening of Soil Metagenomes
Hahk-Soo Kang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Deep sequencing of non-ribosomal peptide synthetases and polyketide synthases from the microbiomes of Australian marine sponges
Jason N. Woodhouse et al.
ISME JOURNAL (2013)
Discovery and Synthetic Refactoring of Tryptophan Dimer Gene Clusters from the Environment
Fang-Yuan Chang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
antiSMASH 2.0-a versatile platform for genome mining of secondary metabolite producers
Kai Blin et al.
NUCLEIC ACIDS RESEARCH (2013)
Alternative Sigma Factor Over-Expression Enables Heterologous Expression of a Type II Polyketide Biosynthetic Pathway in Escherichia coli
David Cole Stevens et al.
PLOS ONE (2013)
Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening
Fang-Yuan Chang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Metagenomic natural product discovery in lichen provides evidence for a family of biosynthetic pathways in diverse symbioses
Annette Kampa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products
Jeremy G. Owen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Refactoring the Silent Spectinabilin Gene Cluster Using a Plug-and-Play Scaffold
Zengyi Shao et al.
ACS SYNTHETIC BIOLOGY (2013)
Natural Product Biosynthetic Gene Diversity in Geographically Distinct Soil Microbiomes
Boojala Vijay B. Reddy et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2012)
Proteasome Inhibitors: An Expanding Army Attacking a Unique Target
Alexei F. Kisselev et al.
CHEMISTRY & BIOLOGY (2012)
Biocatalysts and small molecule products from metagenomic studies
Hala A. Iqbal et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2012)
Nonlinear electrophoresis for purification of soil DNA for metagenomics
Katja Engel et al.
JOURNAL OF MICROBIOLOGICAL METHODS (2012)
Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010
David J. Newman et al.
JOURNAL OF NATURAL PRODUCTS (2012)
Tetarimycin A, an MRSA-Active Antibiotic Identified through Induced Expression of Environmental DNA Gene Clusters
Dimitris Kallifidas et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity
Nadine Ziemert et al.
PLOS ONE (2012)
Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides
Michael F. Freeman et al.
SCIENCE (2012)
Geographic Distribution of Secondary Metabolite Genes in the Marine Actinomycete Salinispora arenicola
Anna Edlund et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2011)
Accessing the Hidden Majority of Marine Natural Products through Metagenomics
Mohamed S. Donia et al.
CHEMBIOCHEM (2011)
Gram negative shuttle BAC vector for heterologous expression of metagenomic libraries
Kavita S. Kakirde et al.
GENE (2011)
Isolation and Characterization of a Novel Tannase from a Metagenomic Library
Jian Yao et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2011)
Cloning and Characterization of an Environmental DNA-Derived Gene Cluster That Encodes the Biosynthesis of the Antitumor Substance BE-54017
Fang-Yuan Chang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
A close relationship between primary nucleotides sequence structure and the composition of functional genes in the genome of prokaryotes
Juan A. L. Garcia et al.
MOLECULAR PHYLOGENETICS AND EVOLUTION (2011)
antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
Marnix H. Medema et al.
NUCLEIC ACIDS RESEARCH (2011)
Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites
Zhiyang Feng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
Luisa Laureti et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Expanding Small-Molecule Functional Metagenomics through Parallel Screening of Broad-Host-Range Cosmid Environmental DNA Libraries in Diverse Proteobacteria
Jeffrey W. Craig et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2010)
Product-Induced Gene Expression, a Product-Responsive Reporter Assay Used To Screen Metagenomic Libraries for Enzyme-Encoding Genes
Taku Uchiyama et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2010)
Sequence-Based Analysis of Secondary-Metabolite Biosynthesis in Marine Actinobacteria
Erin A. Gontang et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2010)
A novel metagenome-derived β-galactosidase: gene cloning, overexpression, purification and characterization
Kui Wang et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2010)
Cloning Large Natural Product Gene Clusters from the Environment: Piecing Environmental DNA Gene Clusters Back Together with TAR
Jeffrey H. Kim et al.
BIOPOLYMERS (2010)
Prospecting Metagenomic Enzyme Subfamily Genes for DNA Family Shuffling by a Novel PCR-based Approach
Qiuyan Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Fluostatins Produced by the Heterologous Expression of a TAR Reassembled Environmental DNA Derived Type II PKS Gene Cluster
Zhiyang Feng et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Tailoring Enzyme-Rich Environmental DNA Clones: A Source of Enzymes for Generating Libraries of Unnatural Natural Products
Jacob J. Banik et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Solution Structure of Polytheonamide B, a Highly Cytotoxic Nonribosomal Polypeptide from Marine Sponge
Toshiyuki Hamada et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Natural Products from Environmental DNA Hosted in Ralstonia metallidurans
Jeffrey W. Craig et al.
ACS CHEMICAL BIOLOGY (2009)
An Environmental DNA-Derived Type II Polyketide Biosynthetic Pathway Encodes the Biosynthesis of the Pentacyclic Polyketide Erdacin
Ryan W. King et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Natural products and drug discovery Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?
Hong-Fang Ji et al.
EMBO REPORTS (2009)
A plasmid RK2-based broad-host-range cloning vector useful for transfer of metagenomic libraries to a variety of bacterial species
Trine Aakvik et al.
FEMS MICROBIOLOGY LETTERS (2009)
Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine
Hirofumi Nakano et al.
JOURNAL OF ANTIBIOTICS (2009)
Nonlinear electrophoretic response yields a unique parameter for separation of biomolecules
Joel Pel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Recovery, purification, and cloning of high-molecular-weight DNA from soil microorganisms
Mark R. Liles et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2008)
Joining the army of proteasome inhibitors
Alexei F. Kisselev
CHEMISTRY & BIOLOGY (2008)
Natural products to drugs: natural product-derived compounds in clinical trials
Mark S. Butler
NATURAL PRODUCT REPORTS (2008)
ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures
Antonio Starcevic et al.
NUCLEIC ACIDS RESEARCH (2008)
Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary
Jacob J. Banik et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Natural products from isnA-containing biosynthetic gene clusters recovered from the genomes of cultured and uncultured bacteria
Sean F. Brady et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Construction of soil environmental DNA cosmid libraries and screening for clones that produce biologically active small molecules
Sean F. Brady
NATURE PROTOCOLS (2007)
Microcolony cultivation on a soil substrate membrane system selects for previously uncultured soil bacteria
BC Ferrari et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2005)
Comparative metagenomics of microbial communities
SG Tringe et al.
SCIENCE (2005)
Quantifying the accessibility of the metagenome by random expression cloning techniques
EM Gabor et al.
ENVIRONMENTAL MICROBIOLOGY (2004)
Long-chain N-acyltyrosine synthases from environmental DNA
SF Brady et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2004)
bryA:: An unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina
M Hildebrand et al.
CHEMISTRY & BIOLOGY (2004)
Integration site for streptomyces phage φBT1 and development of site-specific integrating vectors
MA Gregory et al.
JOURNAL OF BACTERIOLOGY (2003)
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
H Ikeda et al.
NATURE BIOTECHNOLOGY (2003)
The uncultured microbial majority
MS Rappe et al.
ANNUAL REVIEW OF MICROBIOLOGY (2003)
New natural product families from an environmental DNA (eDNA) gene cluster
SF Brady et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
SD Bentley et al.
NATURE (2002)
Pestalone, a new antibiotic produced by a marine fungus in response to bacterial challenge
M Cueto et al.
JOURNAL OF NATURAL PRODUCTS (2001)
Evidence for the biosynthesis of bryostatins by the bacterial symbiont Candidatus Endobugula sertula of the bryozoan Bugula neritina
SK Davidson et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2001)
Quantification of bacterial subgroups in soil:: comparison of DNA extracted directly from soil or from cells previously released by density gradient centrifugation
S Courtois et al.
ENVIRONMENTAL MICROBIOLOGY (2001)
Cloning and heterologous expression of a natural product biosynthetic gene cluster from eDNA
SF Brady et al.
ORGANIC LETTERS (2001)
Novel natural products from soil DNA libraries in a streptomycete host
GYS Wang et al.
ORGANIC LETTERS (2000)
Cloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms
MR Rondon et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2000)