4.5 Article

Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

One-step high-efficiency CRISPR/Cas9-mediated genome editing in Streptomyces

He Huang et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2015)

Review Biotechnology & Applied Microbiology

Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes

Tilmann Weber et al.

TRENDS IN BIOTECHNOLOGY (2015)

Article Biotechnology & Applied Microbiology

Characterization of negative regulatory genes for the biosynthesis of rapamycin in Streptomyces rapamycinicus and its application for improved production

Young Ji Yoo et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2015)

Article Multidisciplinary Sciences

Strain-Level Diversity of Secondary Metabolism in Streptomyces albus

Ryan F. Seipke

PLOS ONE (2015)

Article Biochemical Research Methods

High-Efficiency Multiplex Genome Editing of Streptomyces Species Using an Engineered CRISPR/Cas System

Ryan E. Cobb et al.

ACS SYNTHETIC BIOLOGY (2015)

Article Biochemical Research Methods

Engineering Terpene Biosynthesis in Streptomyces for Production of the Advanced Biofuel Precursor Bisabolene

Ryan M. Phelan et al.

ACS Synthetic Biology (2015)

Article Microbiology

Overproduction of Ristomycin A by Activation of a Silent Gene Cluster in Amycolatopsis japonicum MG417-CF17

Marius Spohn et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)

Article Microbiology

New Insights into Chloramphenicol Biosynthesis in Streptomyces venezuelae ATCC 10712

Lorena T. Fernandez-Martinez et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)

Article Biotechnology & Applied Microbiology

Genome rearrangements of Streptomyces albus J1074 lead to the carotenoid gene cluster activation

Maksym Myronovskyi et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2014)

Article Biotechnology & Applied Microbiology

Novel and tightly regulated resorcinol and cumate-inducible expression systems for Streptomyces and other actinobacteria

Liliya Horbal et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2014)

Article Biotechnology & Applied Microbiology

PAS-LuxR transcriptional control of filipin biosynthesis in S-avermitilis

Claudia M. Vicente et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2014)

Article Biotechnology & Applied Microbiology

Unusual site-specific DNA integration into the highly active pseudo-attB of the Streptomyces albus J1074 genome

Bohdan Bilyk et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2014)

Article Biotechnology & Applied Microbiology

Enhanced production of validamycin A in Streptomyces hygroscopicus 5008 by engineering validamycin biosynthetic gene cluster

Tan-Che Zhou et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2014)

Article Biotechnology & Applied Microbiology

The pathway-specific regulatory genes, tei15* and tei16*, are the master switches of teicoplanin production in Actinoplanes teichomyceticus

Liliya Horbal et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2014)

Article Biotechnology & Applied Microbiology

Iterative marker excision system

Maksym Myronovskyi et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2014)

Article Biochemistry & Molecular Biology

Assembly Line Polyketide Synthases: Mechanistic Insights and Unsolved Problems

Chaitan Khosla et al.

BIOCHEMISTRY (2014)

Article Biotechnology & Applied Microbiology

A novel Streptomyces spp. integration vector derived from the S. venezuelae phage, SV1

Bahgat Fayed et al.

BMC BIOTECHNOLOGY (2014)

Article Biotechnology & Applied Microbiology

Insights into naturally minimised Streptomyces albus J1074 genome

Nestor Zaburannyi et al.

BMC GENOMICS (2014)

Review Biochemistry & Molecular Biology

Mining the Metabiome: Identifying Novel Natural Products from Microbial Communities

Aleksandr Milshteyn et al.

CHEMISTRY & BIOLOGY (2014)

Review Biochemical Research Methods

Recent advances in genome-based polyketide discovery

Eric J. N. Helfrich et al.

CURRENT OPINION IN BIOTECHNOLOGY (2014)

Review Microbiology

Metagenomic small molecule discovery methods

Zachary Charlop-Powers et al.

CURRENT OPINION IN MICROBIOLOGY (2014)

Article Biotechnology & Applied Microbiology

SlnM gene overexpression with different promoters on natamycin production in Streptomyces lydicus A02

Huiling Wu et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2014)

Review Biotechnology & Applied Microbiology

Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways

Gregory L. Challis

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2014)

Review Biotechnology & Applied Microbiology

DNA assembly techniques for next-generation combinatorial biosynthesis of natural products

Ryan E. Cobb et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2014)

Review Biotechnology & Applied Microbiology

Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides

Christopher N. Boddy

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2014)

Review Biotechnology & Applied Microbiology

Importance of microbial natural products and the need to revitalize their discovery

Arnold L. Demain

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2014)

Review Biotechnology & Applied Microbiology

Actinomycetes biosynthetic potential: how to bridge in silico and in vivo?

Yuriy Rebets et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2014)

Review Biotechnology & Applied Microbiology

Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters

Haruo Ikeda et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2014)

Review Biotechnology & Applied Microbiology

Triggers and cues that activate antibiotic production by actinomycetes

Hua Zhu et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2014)

Review Biotechnology & Applied Microbiology

Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?

Brian O. Bachmann et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2014)

Review Biotechnology & Applied Microbiology

Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements

Kozo Ochi et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2014)

Article Biotechnology & Applied Microbiology

MbtH homology codes to identify gifted microbes for genome mining

Richard H. Baltz

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2014)

Review Biotechnology & Applied Microbiology

Genome mining of Streptomyces ambofaciens

Bertrand Aigle et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2014)

Review Biotechnology & Applied Microbiology

Heterologous expression of natural product biosynthetic gene clusters in Streptomyces coelicolor: from genome mining to manipulation of biosynthetic pathways

Juan Pablo Gomez-Escribano et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2014)

Article Biotechnology & Applied Microbiology

SACE_3986, a TetR family transcriptional regulator, negatively controls erythromycin biosynthesis in Saccharopolyspora erythraea

Panpan Wu et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2014)

Article Biotechnology & Applied Microbiology

Effect of Antibiotic Down-Regulatory Gene wblA Ortholog on Antifungal Polyene Production in Rare Actinomycetes Pseudonocardia autotrophica

Hye-Jin Kim et al.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2014)

Review Biochemistry & Molecular Biology

New Applications for Phage Integrases

Paul C. M. Fogg et al.

JOURNAL OF MOLECULAR BIOLOGY (2014)

Article Chemistry, Medicinal

Metabolomic Profiling and Genomic Study of a Marine Sponge-Associated Streptomyces sp.

Christina Viegelmann et al.

MARINE DRUGS (2014)

Article Multidisciplinary Sciences

Structure of a modular polyketide synthase

Somnath Dutta et al.

NATURE (2014)

Article Multidisciplinary Sciences

Structural rearrangements of a polyketide synthase module during its catalytic cycle

Jonathan R. Whicher et al.

NATURE (2014)

Article Biotechnology & Applied Microbiology

Functional optimization of gene clusters by combinatorial design and assembly

Michael J. Smanski et al.

NATURE BIOTECHNOLOGY (2014)

Article Multidisciplinary Sciences

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

Kazuya Yamanaka et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Genetics & Heredity

Generation and study of the strains of streptomycetes-heterologous hosts for the production of moenomycin

M. Lopatniuk et al.

RUSSIAN JOURNAL OF GENETICS (2014)

Article Multidisciplinary Sciences

Use of the Meganuclease I-SceI of Saccharomyces cerevisiae to select for gene deletions in actinomycetes

Lorena T. Fernandez-Martinez et al.

SCIENTIFIC REPORTS (2014)

Article Biochemical Research Methods

A Systematic Computational Analysis of Biosynthetic Gene Cluster Evolution: Lessons for Engineering Biosynthesis

Marnix H. Medema et al.

PLOS COMPUTATIONAL BIOLOGY (2014)

Article Biotechnology & Applied Microbiology

Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074

Carlos Olano et al.

MICROBIAL BIOTECHNOLOGY (2014)

Editorial Material Microbiology

Genome Sequence of Streptomyces wadayamensis Strain A23, an Endophytic Actinobacterium from Citrus reticulata

Luciana G. de Oliveira et al.

GENOME ANNOUNCEMENTS (2014)

Article Biotechnology & Applied Microbiology

Improvement of Natamycin Production by Engineering of Phosphopantetheinyl Transferases in Streptomyces chattanoogensis L10

Hui Jiang et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2013)

Review Biotechnology & Applied Microbiology

New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters

Kozo Ochi et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2013)

Article Biotechnology & Applied Microbiology

In vivo random mutagenesis of streptomycetes using mariner-based transposon Himar1

Bohdan Bilyk et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2013)

Review Chemistry, Organic

The regulation and biosynthesis of antimycins

Ryan F. Seipke et al.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Understanding and manipulating antibiotic production in actinomycetes

Mervyn J. Bibb

BIOCHEMICAL SOCIETY TRANSACTIONS (2013)

Article Biotechnology & Applied Microbiology

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

Wenyan Jiang et al.

NATURE BIOTECHNOLOGY (2013)

Article Biochemical Research Methods

Cas9 as a versatile tool for engineering biology

Prashant Mali et al.

NATURE METHODS (2013)

Article Biotechnology & Applied Microbiology

Design, construction and characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes

Theresa Siegl et al.

METABOLIC ENGINEERING (2013)

Review Microbiology

Molecular Regulation of Antibiotic Biosynthesis in Streptomyces

Gang Liu et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2013)

Article Multidisciplinary Sciences

Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism

Dagmara K. Derewacz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemical Research Methods

Refactoring the Silent Spectinabilin Gene Cluster Using a Plug-and-Play Scaffold

Zengyi Shao et al.

ACS SYNTHETIC BIOLOGY (2013)

Review Biotechnology & Applied Microbiology

An Insight into the -Omics Based Engineering of Streptomycetes for Secondary Metabolite Overproduction

Amit Kumar Chaudhary et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Article Biotechnology & Applied Microbiology

Site-Specific Recombination Strategies for Engineering Actinomycete Genomes

Simone Herrmann et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2012)

Review Biotechnology & Applied Microbiology

Artificial Chromosomes to Explore and to Exploit Biosynthetic Capabilities of Actinomycetes

Rosa Alduina et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2012)

Review Biotechnology & Applied Microbiology

Streptomyces temperate bacteriophage integration systems for stable genetic engineering of actinomycetes (and other organisms)

Richard H. Baltz

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2012)

Article Biochemical Research Methods

Efficient transposition of IS204-derived plasmids in Streptomyces coelicolor

Xincheng Zhang et al.

JOURNAL OF MICROBIOLOGICAL METHODS (2012)

Article Chemistry, Multidisciplinary

Tetarimycin A, an MRSA-Active Antibiotic Identified through Induced Expression of Environmental DNA Gene Clusters

Dimitris Kallifidas et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Multidisciplinary Sciences

Refactoring the nitrogen fixation gene cluster from Klebsiella oxytoca

Karsten Temme et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biotechnology & Applied Microbiology

Titer improvement of iso-migrastatin in selected heterologous Streptomyces hosts and related analysis of mRNA expression by quantitative RT-PCR

Dong Yang et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2011)

Article Biotechnology & Applied Microbiology

The construction of a library of synthetic promoters revealed some specific features of strong Streptomyces promoters

Nicolas Seghezzi et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2011)

Article Microbiology

Whole Genome Sequence of the Rifamycin B-Producing Strain Amycolatopsis mediterranei S699

Mansi Verma et al.

JOURNAL OF BACTERIOLOGY (2011)

Article Microbiology

ZouA, a Putative Relaxase, Is Essential for DNA Amplification in Streptomyces kanamyceticus

Takeshi Murakami et al.

JOURNAL OF BACTERIOLOGY (2011)

Article Microbiology

Genome Sequence of the Spinosyns-Producing Bacterium Saccharopolyspora spinosa NRRL 18395

Yuanlong Pan et al.

JOURNAL OF BACTERIOLOGY (2011)

Review Biotechnology & Applied Microbiology

Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery

Richard H. Baltz

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2011)

Review Biotechnology & Applied Microbiology

Strain improvement in actinomycetes in the postgenomic era

Richard H. Baltz

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2011)

Review Biochemistry & Molecular Biology

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

Gilles P. van Wezel et al.

NATURAL PRODUCT REPORTS (2011)

Article Biotechnology & Applied Microbiology

Functional conservation of PAS-LuxR transcriptional regulators in polyene macrolide biosynthesis

Javier Santos-Aberturas et al.

METABOLIC ENGINEERING (2011)

Article Multidisciplinary Sciences

A system for the targeted amplification of bacterial gene clusters multiplies antibiotic yield in Streptomyces coelicolor

Takeshi Murakami et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

Luisa Laureti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biotechnology & Applied Microbiology

Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus

Marnix H. Medema et al.

MICROBIAL BIOTECHNOLOGY (2011)

Article Biotechnology & Applied Microbiology

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters

Juan Pablo Gomez-Escribano et al.

MICROBIAL BIOTECHNOLOGY (2011)

Article Biotechnology & Applied Microbiology

Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis

Yvonne Mast et al.

MICROBIAL BIOTECHNOLOGY (2011)

Review Biotechnology & Applied Microbiology

Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation

Yihua Chen et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2010)

Article Biotechnology & Applied Microbiology

Use of an inducible promoter for antibiotic production in a heterologous host

Volker Dangel et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2010)

Article Biotechnology & Applied Microbiology

I-SceI endonuclease: a new tool for DNA repair studies and genetic manipulations in streptomycetes

Theresa Siegl et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2010)

Article Biochemistry & Molecular Biology

Identification of the Tirandamycin Biosynthetic Gene Cluster from Streptomyces sp 307-9

Jacob C. Carlson et al.

CHEMBIOCHEM (2010)

Review Biotechnology & Applied Microbiology

Biosynthesis of rapamycin and its regulation: past achievements and recent progress

Sung Ryeol Park et al.

JOURNAL OF ANTIBIOTICS (2010)

Article Biotechnology & Applied Microbiology

Genomics and the ancient origins of the daptomycin biosynthetic gene cluster

Richard H. Baltz

JOURNAL OF ANTIBIOTICS (2010)

Review Biotechnology & Applied Microbiology

Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters

Richard H. Baltz

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2010)

Article Biotechnology & Applied Microbiology

Genetic factors that influence moenomycin production in streptomycetes

Roman Makitrynskyy et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2010)

Article Biotechnology & Applied Microbiology

Overexpression of ribosome recycling factor causes increased production of avermectin in Streptomyces avermitilis strains

Lili Li et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2010)

Article Chemistry, Multidisciplinary

Tailoring Enzyme-Rich Environmental DNA Clones: A Source of Enzymes for Generating Libraries of Unnatural Natural Products

Jacob J. Banik et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Chemistry, Multidisciplinary

Natural Products Version 2.0: Connecting Genes to Molecules

Christopher T. Walsh et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Multidisciplinary Sciences

Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis

Ying Zhuo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

Mamoru Komatsua et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biotechnology & Applied Microbiology

Antibiotic Overproduction by rpsL and rsmG Mutants of Various Actinomycetes

Yukinori Tanaka et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2009)

Article Biotechnology & Applied Microbiology

Characterization of rrdA, a TetR Family Protein Gene Involved in the Regulation of Secondary Metabolism in Streptomyces coelicolor

Xijun Ou et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2009)

Article Biotechnology & Applied Microbiology

In vivo Tn5-based transposon mutagenesis of Streptomycetes

Lutz Petzke et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2009)

Article Biochemistry & Molecular Biology

Engineered production of iso-migrastatin in heterologous Streptomyces hosts

Zhiyang Feng et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2009)

Article Biotechnology & Applied Microbiology

Automated design of synthetic ribosome binding sites to control protein expression

Howard M. Salis et al.

NATURE BIOTECHNOLOGY (2009)

Article Biotechnology & Applied Microbiology

Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12

Takeshi Hosaka et al.

NATURE BIOTECHNOLOGY (2009)

Article Biotechnology & Applied Microbiology

Dramatic activation of antibiotic production in Streptomyces coelicolor by cumulative drug resistance mutations

Guojun Wang et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2008)

Review Pharmacology & Pharmacy

Renaissance in antibacterial discovery from actinomycetes

Richard H. Baltz

CURRENT OPINION IN PHARMACOLOGY (2008)

Review Biotechnology & Applied Microbiology

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

Carlos Olano et al.

METABOLIC ENGINEERING (2008)

Article Multidisciplinary Sciences

A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea

Chinping Chng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biotechnology & Applied Microbiology

Identification of the biosynthetic gene cluster and an additional gene for resistance to the antituberculosis drug capreomycin

Elizabeth A. Felnagle et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2007)

Article Biotechnology & Applied Microbiology

Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338

Markiyan Oliynyk et al.

NATURE BIOTECHNOLOGY (2007)

Article Biochemistry & Molecular Biology

Evolution of the terminal regions of the streptomyces linear chromosome

Frederic Choulet et al.

MOLECULAR BIOLOGY AND EVOLUTION (2006)

Article Multidisciplinary Sciences

Combinatorial biosynthesis of novel antibiotics related to daptomycin

Kien T. Nguyen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

A dedicated phosphopantetheinyl transferase for the fredericamycin polyketide synthase from Streptomyces griseus

Yong Huang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Microbiology

The enduracidin biosynthetic gene cluster from Streptomyces fungicidicus

Xihou Yin et al.

MICROBIOLOGY-SGM (2006)

Review Chemistry, Multidisciplinary

Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: Logic, machinery, and mechanisms

Michael A. Fischbach et al.

CHEMICAL REVIEWS (2006)

Article Biotechnology & Applied Microbiology

Marcel Faber Roundtable: Is our antibiotic pipeline unproductive because of starvation, constipation or lack of inspiration?

Richard H. Baltz

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2006)

Article Multidisciplinary Sciences

Amplification of the entire kanamycin biosynthetic gene cluster during empirical strain improvement of Streptomyces kanamyceticus

Koji Yanai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biotechnology & Applied Microbiology

The lipopeptide antibiotic A54145 biosynthetic gene cluster from Streptomyces fradiae

V Miao et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2006)

Article Biochemical Research Methods

In vitro 'sexual' evolution through the PCR-based staggered extension process (StEP)

Huimin Zhao et al.

NATURE PROTOCOLS (2006)

Article Biotechnology & Applied Microbiology

Spectinomycin resistance in rpsE mutants is recessive in Streptomyces roseosporus

XW He et al.

JOURNAL OF ANTIBIOTICS (2005)

Article Biochemistry & Molecular Biology

Positive control of tylosin biosynthesis: pivotal role of TylR

G Stratigopoulos et al.

MOLECULAR MICROBIOLOGY (2004)

Article Biotechnology & Applied Microbiology

Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays

AM Lum et al.

METABOLIC ENGINEERING (2004)

Article Biochemistry & Molecular Biology

The gene cluster for the biosynthesis of the glycopeptide antibiotic A40926 by Nonomuraea species

M Sosio et al.

CHEMISTRY & BIOLOGY (2003)

Article Multidisciplinary Sciences

Assembling the glycopeptide antibiotic scaffold:: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL 15009

J Pootoolal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Multidisciplinary Sciences

Genome shuffling leads to rapid phenotypic improvement in bacteria

YX Zhang et al.

NATURE (2002)

Article Biotechnology & Applied Microbiology

Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis:: analysis of enzymatic domains in four polyketide synthases

H Ikeda et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2001)

Article Biochemistry & Molecular Biology

Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa

C Waldron et al.

CHEMISTRY & BIOLOGY (2001)

Article Microbiology

Genetic methods and strategies for secondary metabolite yield improvement in actinomycetes

RH Baltz

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2001)