Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 22, Pages 6641-6644Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201500674
Keywords
hydrogels; photonic crystals; polymers; responsive materials; sensors
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Funding
- German Federal Ministry of Education and Research (BMBF), initiative Spitzenforschung & Innovation in den neuen Landern, cooperative project Das Taschentuchlabor-Impulszentrum fur Integrierte Bioanalyse [FKZ 03IS2201 B/C]
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Dual responsive inverse opal hydrogels were designed as autonomous sensor systems for (bio)macromolecules, exploiting the analyte-induced modulation of the opal's structural color. The systems that are based on oligo(ethylene glycol) macromonomers additionally incorporate comonomers with various recognition units. They combine a coil-to-globule collapse transition of the LCST type with sensitivity of the transition temperature toward molecular recognition processes. This enables the specific detection of macromolecular analytes, such as glycopolymers and proteins, by simple optical methods. While the inverse opal structure assists the effective diffusion even of large analytes into the photonic crystal, the stimulus responsiveness gives rise to strong shifts of the optical Bragg peak of more than 100nm upon analyte binding at a given temperature. The systems' design provides a versatile platform for the development of easy-to-use, fast, and low-cost sensors for pathogens.
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