Journal
JOURNAL OF IMMUNOLOGY
Volume 194, Issue 6, Pages 2467-2471Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1402756
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Funding
- Swedish Research Council
- German Research Foundation
- Swedish Cancer Society
- Swedish Society for Medical Research
- Cancer Research Foundations of Radiumhemmet
- Swedish Society of Medicine
- Novo Nordisk Foundation
- Ake Olsson's Foundation
- Jeansson's Foundation
- Bengt Ihre's Foundation
- Groschinsky's Foundation
- Hedlunds' Foundation
- Julin's Foundation
- Novo Nordisk Fonden [NNF14OC0009347] Funding Source: researchfish
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Although NK cells are considered innate, recent studies in mice revealed the existence of a unique lineage of hepatic CD49a(+)DX5(-) NK cells with adaptive-like features. Development of this NK cell lineage is, in contrast to conventional NK cells, dependent on T-bet but not Eomes. In this study, we describe the identification of a T-bet(+)Eomes(-)CD49a(+) NK cell subset readily detectable in the human liver, but not in afferent or efferent hepatic venous or peripheral blood. Human intrahepatic CD49a(+) NK cells express killer cell Ig-like receptor and NKG2C, indicative of having undergone clonal-like expansion, are CD56(bright), and express low levels of CD16, CD57, and perforin. After stimulation, CD49a(+) NK cells express high levels of inflammatory cytokines but degranulate poorly. CD49a(+) NK cells retain their phenotype after expansion in long-term in vitro cultures. These results demonstrate the presence of a likely human counterpart of mouse intrahepatic NK cells with adaptive-like features.
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