Journal
JOURNAL OF IMMUNOLOGY
Volume 194, Issue 2, Pages 491-497Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1401214
Keywords
-
Categories
Funding
- University Medical Center Utrecht
- Netherlands Organization for Scientific Research [916.66.044]
Ask authors/readers for more resources
Granzymes (Grs) are serine proteases mainly produced by cytotoxic lymphocytes and are traditionally considered to cause apoptosis in tumor cells and virally infected cells. However, the cytotoxicity of several Grs is currently being debated, and additional, predominantly extracellular, functions of Grs in inflammation are emerging. Extracellular soluble Grs are elevated in the circulation of patients with autoimmune diseases and infections. Additionally, Grs are expressed by several types of immune cells other than cytotoxic lymphocytes. Recent research has revealed novel immunomodulatory functions of Grs. In this review, we provide a comprehensive overview on the role of Grs in inflammation, highlighting their role in cytokine induction and processing.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available