Journal
JOURNAL OF IMMUNOLOGY
Volume 195, Issue 12, Pages 5525-5531Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1501686
Keywords
-
Categories
Funding
- National Institutes of Health [R01 DK076690]
Ask authors/readers for more resources
Complement activation is an important cause of tissue injury in patients with Ab-mediated rejection (AMR) of transplanted organs. Complement activation triggers a strong inflammatory response, and it also generates tissue-bound and soluble fragments that are clinically useful markers of inflammation. The detection of complement proteins deposited within transplanted tissues has become an indispensible biomarker of AMR, and several assays have recently been developed to measure complement activation by Abs reactive to specific donor HLA expressed within the transplant. Complement inhibitors have entered clinical use and have shown efficacy for the treatment of AMR. New methods of detecting complement activation within transplanted organs will improve our ability to diagnose and monitor AMR, and they will also help guide the use of complement inhibitory drugs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available