Journal
JOURNAL OF IMMUNOLOGY
Volume 195, Issue 9, Pages 4257-4263Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1402584
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Funding
- Erasmus Medical Center grant
- ZenithII Grant by the Netherlands Genomics Initiative [93512004]
- Medical Research Council [G0601156]
- Human Frontier Science Program [RGP0006/2009-C]
- People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7 under Research Executive Agency [289720]
- MRC [G0601156, MR/K021125/1] Funding Source: UKRI
- Medical Research Council [MR/K021125/1, G0601156] Funding Source: researchfish
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Adaptive immunity critically depends on the functional compartmentalization of secondary lymphoid organs. Mesenchymal stromal cells create and maintain specialized niches that support survival, activation, and expansion of T and B cells, and integrated analysis of lymphocytes and their niche has been instrumental in understanding adaptive immunity. Lymphoid organs are also home to type 3 innate lymphoid cells (ILC3), innate effector cells essential for barrier immunity. However, a specialized stromal niche for ILC3 has not been identified. A novel lineage-tracing approach now identifies a subset of murine fetal lymphoid tissue organizer cells that gives rise exclusively to adult marginal reticular cells. Moreover, both cell types are conserved from mice to humans and colocalize with ILC3 in secondary lymphoid tissues throughout life. In sum, we provide evidence that fetal stromal organizers give rise to adult marginal reticular cells and form a dedicated stromal niche for innate ILC3 in adaptive lymphoid organs.
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