Journal
CHINESE JOURNAL OF POLYMER SCIENCE
Volume 32, Issue 10, Pages 1413-1418Publisher
SPRINGER
DOI: 10.1007/s10118-014-1517-7
Keywords
Chitosan; Sodium alginate; Photosensitizer; Photoactivity; Quenching
Categories
Funding
- National Natural Science Foundation of China [21244005, 20974130]
- Science and Technology Planning Project of Guangdong Province, China [2012B091100356]
Ask authors/readers for more resources
Photosensitizer (photosan)-encapsulated micelles were prepared by self-assembly of Photosan with two amphiphilic polysaccharide derivatives, including the cholesteryl conjugated sodium alginate derivative (CSAD) and the deoxycholic acid group conjugated chitosan derivative (DA-Chit). The results of UV-Vis and fluorescence spectroscopy indicated that the hydrogen bonding strength dominated the micelle formation. Methyl viologen was used as a model quencher of photosan. Using the steady-state fluorescence technology, the quenching constants were determined to be 2.05, 1.88 and 0.30 L/mmol for the free photosan, the photosan-CSAD micelle and the photosan-DA-Chit micelle, respectively. This suggested that photosan was protected from quenching of methyl viologen by the polysaccharide micelles. In addition, the protection effect of the photosan-DA-Chit micelle was significantly stronger than that of the photosan-CSAD micelle. The photosan-DA-Chit micelle is thus anticipated for protection of photoactivity of photosan during the blood circulation process in vivo.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available