Journal
CHINESE JOURNAL OF POLYMER SCIENCE
Volume 30, Issue 2, Pages 235-241Publisher
SPRINGER
DOI: 10.1007/s10118-012-1118-2
Keywords
Poly(N-vinylpyrrolidone); Surface modification; Protein adsorption; ATRP; Biocompatibility
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Funding
- National Natural Science Foundation of China [20974086, 20974122, 20920102035]
- Ministry of Education of China [209151]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars
- State Education Ministry
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The present work aimed to study the interaction between plasma proteins and PVP-modified surfaces under more complex protein conditions. In the competitive adsorption of fibrinogen (Fg) and human serum albumin (HSA), the modified surfaces showed preferential adsorption of HSA. In 100% plasma, the amount of Fg adsorbed onto PVP-modified surfaces was as low as 10 ng/cm(2), suggesting the excellent protein resistance properties of the modified surfaces. In addition, immunoblots of proteins eluted from the modified surfaces after plasma contact confirmed that PVP-modified surfaces can repel most plasma proteins, especially proteins that play important roles in the process of blood coagulation.
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