Journal
CHINESE JOURNAL OF POLYMER SCIENCE
Volume 30, Issue 5, Pages 719-726Publisher
SPRINGER
DOI: 10.1007/s10118-012-1156-9
Keywords
BSA nanoparticle; PEG; LBL; Drug delivery; pH-responsive
Categories
Funding
- Zhejiang Provincial Natural Science Foundation of China [Z4090177, Y4110064]
- Ministry of Science and Technology of China for the Indo-China Cooperation [2010DFA51510]
- National Natural Science Foundation of China [51120135001, 21174130]
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To improve the colloidal stability of bovine serum albumin (BSA) nanoparticles (NPs) in diverse mediums, poly(allylamine hydrochloride) (PAH)/sodium poly(4-styrene sulfonate) (PSS) multilayers and poly(allylamine hydrochloride)-graft-poly(ethylene glycol) (PAH-g-PEG) coating were coated on the surface of BSA NPs. Stabilities of the BSA NPs in diverse mediums with different surfaces were detected by dynamic light scattering (DLS). Multilayers and PAH-g-PEG coated BSA NPs can be well dispersed in various mediums with a narrow polydispersity index (PDI). The BSA NPs with the highest surface density of PEG show the best stability. The multilayers and PAH-g-PEG coating do not deter the pH-dependent loading and release property of BSA NPs. At pH 9, the encapsulation efficiency of doxorubicin reaches almost 99%, and the release rate at pH 5.5 is significantly higher than that at pH 7.4.
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