Journal
CHINESE JOURNAL OF POLYMER SCIENCE
Volume 28, Issue 4, Pages 555-561Publisher
SPRINGER
DOI: 10.1007/s10118-010-9087-9
Keywords
Chitosan membrane; Hydroxyapatite; In situ compositing; Periodontal tissue regeneration
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Funding
- National Natural Science Foundation of China [50773070]
- Key Basic Research Development Plan (Project 973) of China [2005CB623902]
- Grand Science and Technology Special Project of Zhejiang Province [2008C11087]
- Science and Technology Project of Zhejiang Province [2006C33067]
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In an effort to develop biomaterials to meet guided tissue regeneration (GTR) standards for periodontal tissue recovery, a homogeneous and transparent chitosan (CS)/hydroxyapatite (HA) membrane with potential applications as GTR barrier in periodontal therapy has been prepared via in situ compositing. The membrane has been designed to have a smooth-rough asymmetric structure that meets the demand for GTR. Component and morphology of the membrane are characterized by XRD and SEM. It can be indicated that HA was in situ synthesized uniformly in the CS membrane. Mechanical experiments of the membranes with various HA contents show that their tensile strengths are adequate for periodontal therapy. Biological properties of the membrane have been performed by cell toxicity assays, hemolysis tests and animal experiments. Results indicate that the membrane has good biocompatibility and inductive effect for cell growth. Therefore this membrane can be potentially applied as GTR barrier membrane for periodontal tissue regeneration.
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