Journal
JOURNAL OF IMMUNOLOGY
Volume 194, Issue 12, Pages 5588-5593Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1500395
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Funding
- Digestive Disease Research Core Center [DK42086]
- National Institutes of Health Training Grant [T32 AI007090]
- Kenneth Rainin Foundation
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Fucose is an L-configuration sugar found abundantly in the mammalian gut. It has long been known to be induced there by the presence of bacteria, but only recently have some of the molecular mechanisms behind this process been uncovered. New work suggests that fucose can have a protective role in both gut-centered and systemic infection and inflammation. This review highlights recent studies showing that, in addition to acting as a food source for beneficial gut symbionts, host fucose can suppress the virulence of pathogens and pathobionts. The relevance of gut fucosylation to human diseases also is discussed.
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