Journal
JOURNAL OF IMMUNOLOGY
Volume 195, Issue 10, Pages 4578-4582Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1501157
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Funding
- X.M.L.'s startup funds
- Virginia Bioinformatics Institute
- Fralin Life Science Institute Small Grants Program [VBI/Fralin-GRL-01]
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Plasmacytoid dendritic cells (pDCs) are professional type I IFN producers believed to promote lupus. However, questions exist about whether they function at the same level throughout the course of lupus disease. We analyzed high-purity pDCs sorted from lupus mice. Although pDCs produced a large amount of IFN-alpha during disease initiation, those sorted from late-stage lupus mice were found to be defective in producing IFN-alpha. These pDCs expressed an increased level of MHC, suggesting a functional drift to Ag presentation. We examined the potential mechanism behind the defect and identified a novel transcriptional factor, Foxj2, which repressed the expression of several genes in pDCs, but not IFN-alpha. Dysregulation in pDCs appears to be predisposed, because they exhibited an altered transcriptional profile before the onset of clinical signs. Our results suggest that pDCs do not function the same throughout the disease course and lose the ability to produce IFN-alpha in late-stage lupus mice.
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