Journal
CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
Volume 30, Issue 2, Pages 305-314Publisher
SCIENCE PRESS
DOI: 10.1007/s00343-012-1075-1
Keywords
bioguided isolation; deep-sea sediment-derived fungus; Penicillium commune; xanthocillin X; antibacterial activity; cytotoxicity
Categories
Funding
- Ministry of Science and Technology [2010CB833802]
- Chinese Academy of Sciences [KSCX2-EW-G-12B]
- National Natural Science Foundation of China [30910103914]
Ask authors/readers for more resources
Bioassay-guided fractionation of the crude extract from Penicillium commune SD-118, a fungus obtained from a deep-sea sediment sample, resulted in the isolation of a known antibacterial compound, xanthocillin X (1), and 14 other known compounds comprising three steroids (2-4), two ceramides (5 and 6), six aromatic compounds (7-12), and three alkaloids (13-15). Xanthocillin X (1) was isolated for the first time from a marine fungus. In the bioassay, xanthocillin X (1) displayed remarkable antimicrobial activity against Staphylococcus aureus and Escherichia coli, and significant cytotoxicity against MCF-7, HepG2, H460, Hela, Du145, and MDA-MB-231 cell lines. Meleagrin (15) exhibited cytotoxicity against HepG2, Hela, Du145, and MDA-MB-231 cell lines. This is the first report of the cytotoxicity of xanthocillin X (1).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available