Journal
JOURNAL OF IMMUNOLOGICAL METHODS
Volume 421, Issue -, Pages 36-43Publisher
ELSEVIER
DOI: 10.1016/j.jim.2015.02.005
Keywords
Oral tolerance; Feeding protocols; Continuous feeding; Gavage; Gut mucosa
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Funding
- Fundacao de Amparo a Pesquisas do Estado de Minas Gerais (FAPEMIG)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil
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The ability to avoid inflammatory responses to dietary components and microbiota antigens in the gut mucosa is achieved by a mechanism termed oral tolerance. This phenomenon is crucial to maintain the physiological immune activity in the gut and to prevent inflammatory disorders such as food allergy and inflammatory bowel diseases. Moreover, orally administered antigens induce regulatory cells that control systemic inflammatory responses as well. Given its specific, systemic and long-lasting effects, oral tolerance represents a promising approach for immumotherapies that aim to modulate inflammatory and autoimmune diseases. However, there are different protocols of feeding for induction of oral tolerance, and they have an impact in tolerance efficiency and length. Herein, we present and discuss different experimental feeding protocols and how they influence the outcome of oral administration of antigens. (C) 2015 Elsevier B.V. All rights reserved.
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