Journal
CHINESE JOURNAL OF CHEMISTRY
Volume 31, Issue 7, Pages 878-884Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.201300365
Keywords
olefination; aldehydes; nucleophilic addition; sulfones; fluorine
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Funding
- National Natural Science Foundation of China [20825209, 21202189]
- National Basic Research Program of China [2012CB215500, 2012CB821600]
- Chinese Academy of Sciences
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A highly stereoselective synthesis of tetrasubstituted monofluoroalkenes with aldehydes and fluorobis(phenylsulfonyl)methane (FBSM) in one pot has been developed. The reaction was amenable to para- and meta-substituted aryl aldehydes, 2-naphthaldehyde, and cinnamaldehyde, giving phenylsulfonyl-substituted monofluoroalkenes in 40%-86% yields with 98/2-99/1 Z/E ratios. The presence of the sulfonyl group enables the further transformation of the products into more useful monofluoroalkenes.
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