4.5 Article

Facile Synthesis of 3-Substituted Isoquinolines Derivatives via Microwave-assisted Tandem Three-component Coupling Cyclization

Journal

CHINESE JOURNAL OF CHEMISTRY
Volume 30, Issue 5, Pages 1075-1082

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.201100560

Keywords

palladium; copper-catalyst; microwave; isoquinolines; tandem reaction; coupling cyclization

Funding

  1. National Natural Science Foundation of China [21002038]
  2. CCNU from the Colleges' Basic Research and Operation of MOE [CCNU09A01014]

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A novel three-component reaction of o-bromobenzaldehyde, terminal alkynes and tert-butyl amine has been established, which proceeded smoothly to give 3-substituted isoquinolines in good yields in the presence of palladium/copper catalysts under microwave irradiation.

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