Journal
CHINESE JOURNAL OF CHEMISTRY
Volume 30, Issue 7, Pages 1548-1554Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.201100657
Keywords
spiro compound; isatin; multicomponent reaction; electron-deficient alkyne; 1; 4-dihydropyridine
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Funding
- National Natural Science Foundation of China [21172189]
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An efficient synthetic procedure for the functionalized spiro[indoline-3,4'-pyridine] was developed via the four-component reactions of arylamines, acetylenedicarboxylates, isatins and malononitrile with triethylamine as the base catalyst. The advantages of this reaction are using common starting material, mild reaction conditions, broad scope of reactants and operational simplicity.
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