Journal
CHINESE JOURNAL OF CHEMISTRY
Volume 29, Issue 8, Pages 1727-1731Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.201180308
Keywords
benzo[4,5]imidazo[1,2-a]thiopyrano[3,4-d]pyrimidin-4(3H)-one; multicomponent reactions; combinatorial chemistry
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Funding
- Natural Science Foundation of the Jiangsu Higher Education Institutions [09KJA430003]
- Natural Science Foundation of Xuzhou City [XM09B016]
- Graduate Foundation of Xuzhou Normal University [09YLB030]
- Qing Lan Project [08QLT001]
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A series of novel fused tetracyclic benzo[4,5]imidazo[1,2-a]thiopyrano[3,4-d]pyrimidin-4(3H)-one derivatives were synthesized via the reaction of aryl aldehyde, 2H-thiopyran-3,5(4H,6H)-dione, and 1H-benzo[d]imidazol-2-amine in glacial acetic acid. This protocol features mild reaction conditions, high yields and short reaction time.
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