Journal
CHINESE JOURNAL OF CHEMISTRY
Volume 27, Issue 2, Pages 365-368Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.200990059
Keywords
fungus; xylopyridine A; isolation; metabolite; fluorescence; CT DNA-binding
Categories
Funding
- National Natural Science Foundation of China [20772162, 20572136]
- 863 Foundation of China [2007AA09Z448, 2006AA09Z422]
- Science Foundation of Guangdong Province, China [2007A032600001]
- Star Lake Biotechnology Co., Inc, Zhaoqing, Guangdong, China
Ask authors/readers for more resources
A novel metabolite xylopyridine A (1), together with a known compound pyrocoll (2), was isolated from mangrove endophytic fungus Xylaria sp. (#2508) collected from the South China Sea coast. Their structures were established on the basis of spectroscopic analysis, especially 2D-NMR. Their affinities toward calf thymus (CT) DNA were studied by fluorescence quenching and spectrophotometric titration experiments. The results indicate that 1 showes strong DNA-binding affinity presumably via an intercalation mechanism, thus it is exploitable as strong DNA-binders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available